منابع مشابه
Dopamine release in the basal ganglia.
Dopamine (DA) is a key transmitter in the basal ganglia, yet DA transmission does not conform to several aspects of the classic synaptic doctrine. Axonal DA release occurs through vesicular exocytosis and is action potential- and Ca²⁺-dependent. However, in addition to axonal release, DA neurons in midbrain exhibit somatodendritic release by an incompletely understood, but apparently exocytotic...
متن کاملTask-related interaction between basal ganglia and cortical dopamine release.
Dopamine (DA) is a powerful neuromodulator for a wide variety of behaviors. Considerable evidence accumulated from rodent and monkey experiments over the last two decades suggests that DA activity in the frontal cortex is reciprocally linked to that in functionally related basal ganglia (BG) structures. However, the functional importance of this in humans is still unknown. To address this issue...
متن کاملProperties of dopamine release and uptake in the songbird basal ganglia.
Vocal learning in songbirds requires a basal ganglia circuit termed the anterior forebrain pathway (AFP). The AFP is not required for song production, and its role in song learning is not well understood. Like the mammalian striatum, the striatal component of the AFP, Area X, receives dense dopaminergic innervation from the midbrain. Since dopamine (DA) clearly plays a crucial role in basal gan...
متن کاملSinging to the tune of dopamine. Focus on "Properties of dopamine release and uptake in the songbird basal ganglia".
The mammalian striatum, the input nucleus of the basal ganglia, participates in sensorimotor functions that include motor control as well as the learning of behaviors and behaviorally relevant cues. A key player in striatal learning is dopamine. When released from mesostriatal axons, dopamine is thought to provide an error or “teaching” signal for learning behaviorally relevant stimuli and habi...
متن کاملRGS9 Modulates Dopamine Signaling in the Basal Ganglia
Regulators of G protein signaling (RGS) modulate heterotrimeric G proteins in part by serving as GTPase-activating proteins for Galpha subunits. We examined a role for RGS9-2, an RGS subtype highly enriched in striatum, in modulating dopamine D2 receptor function. Viral-mediated overexpression of RGS9-2 in rat nucleus accumbens (ventral striatum) reduced locomotor responses to cocaine (an indir...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2011
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2011.08.066